UniFluVec™ platform confers protection different subtypes of influenza virus

We are pleased to highlight a significant new publication from Capricorn, entitled UniFluVec influenza vector induces heterosubtypic protection in ferrets after intranasal administration despite high attenuation Science Open.  This study explores the potential of the UniFluVec™ platform to confer protection against influenza virus of different subtype even when the vaccine is highly attenuated. Using the ferret model—a critical standard in influenza research—the authors demonstrate that a single high-dose intranasal immunization with the highly attenuated UniFluVec^tm virus was sufficient to confer protection against a heterologous seasonal influenza virus strain, eliminating the need for booster vaccination.